CHARACTERISTICS OF METABOLIC PROCESSES IN THE FORMATION OF MENSTRUAL FUNCTION DISORDERS IN ADOLESCENT GIRLS WITH OBESITY

Іntroduction. Today, a quarter of the population economically developed countries has body weight that is 15% larger than norm. According to various authors, timely onset menarche in women with forms obesity and reproductive dysfunction observed 31% cases only.
 Obesity results insulin resistance, which its turn hyperinsulinemia. The main reason connection resistance function disorders consists specific influence on ovaries. Insulin suppresses apoptosis, binding receptors growth factors promotes long existence atresizing follicles. In pathogenesis metabolic syndrome, along development hyperinsulinemia significant role belongs imbalance adipocytokines, one adiponectin.
 aim analyze processes formation menstrual adolescent girls improve diagnostic methods disorders.
 Material methods. Clinical laboratory examination aged 12-18 years was held, among 79 had complaints about (the group); 31 normal regular cycle control group).
 Research methods: general clinical, biochemical (indicators lipid carbohydrate metabolism were determined), instrumental (ultrasound), statistical.
 Results. It found 53.3% from group beginning first menstruation after 14 years, delayed 42 days 6 days, duration 2.1 ± 0.05 significantly shorter, volume 10.2 0.05; 0.4 points (average 1-2 pads per day) lower (p <0.05).
 Ultrasound showed uterine hypoplasia almost every second girl - 36 (45.46%).
 Hyperleptinemia leptin degree 34.8 1.75, 37.15 2.12, third 40.64 2.0. 14.35 ng / ml group, p<0,01.
 accompanied by 26% resistance. relationship between low values adiponectin elevated mass index patients established, confirmed correlation analysis (adiponectin & index: ρ = -0.74).
 Analysis revealed decrease A/L level 4.3 times. Based our own results, HOMA-AD models can be considered more accurate for determining resistance.
 Conclusions. 1. Changes overweight found.
 
 association adipokines secretion characterized hyperleptinemia, decreased Adiponectin Leptin hypoadiponectinemia, which, combination indicates participation genesis oligomenorrhea.
 algorithm adolescents’ treatment background must include calculation Adiponectin/Leptin HOMA-AD, will make it possible avoid overdiagnosis